To increase the solubility of iodine and iodine releasing agents, which are used widely as a topical broad spectrum antiseptics and disinfectant sanitizers, its inclusion complexes were prepared and studied. Inclusion complexes of iodine with
β-cyclodextrin were prpared by coprecipitation method and complex formation was acertained by differential scanning calorimetry and microscopic observation, Iodine content of inclusion complex was determined by means of iodometry. Tablets
containing
inclusin complexwere manufactured with sugar, cittric acid, magnesium stearate, dextrose. Stability of inclusion complexes and tablets was evaluated by accelerated stability test, and comparing with PVP-iodine. During preparation, use of 50%
ethanol
solution is preferable to water as the medium because the former resulted in more stable complex for a month under accelerated storage conditions. Solubility of iodine in KI aqueous solution was 0.048g/ml and lower than in 50% ethanol solution,
Inclusion complex and its tablets were very stable at severe condition for one month, and comparable to PVP-iodine in the aspect of stability. Inclusion complex tabletswere not affected with citric acid, sugar, dextrose, and direct tableting
method was
recommendable because wet granulation using ethanol gave some release of included iodine during process.
|